The Student News Site of Texas A&M University - College Station

The Battalion

The Student News Site of Texas A&M University - College Station

The Battalion

The Student News Site of Texas A&M University - College Station

The Battalion

Texas A&M University System Chancellor John Sharp attends the Class of 1972 50-year reunion in Kyle Field on April 20, 2022.
A&M System’s Title IX director suspended after supporting Biden's Title IX changes
Nicholas Gutteridge, Managing Editor • May 23, 2024
Texas A&M utility Gavin Grahovac (9) throws the ball during A&Ms game against Georgia on Friday, April 26, 2024, at Olsen Field. (CJ Smith/The Battalion)
Southern slugfest
Shalina Sabih, Sports Writer • May 23, 2024

The No. 3 Texas A&M baseball team took on No. 1 Tennessee Thursday at 1 p.m. at Hoover Metropolitan Stadium in Hoover, Alabama. Despite its...

Texas A&M pitcher Evan Aschenbeck (53) reacts after throwing the final strike out during Texas A&M’s game against Mississippi State on Saturday, March 23, 2024, at Olsen Field. (Chris Swann/ The Battalion)
Down but not out
May 23, 2024
Beekeeper Shelby Dittman scoops bees back into their hive during a visit on Friday, April 5, 2024. (Kyle Heise/The Battalion)
Bee-hind the scenes
Shalina Sabih, Sports Writer • May 1, 2024

The speakers turn on. Static clicks. And a voice reads “Your starting lineup for the Texas A&M Aggies is …” Spectators hear that...

Kennedy White, 19, sits for a portrait in the sweats she wore the night of her alleged assault inside the Y.M.C.A building that holds Texas A&M’s Title IX offices in College Station, Texas on Feb. 16, 2024 (Ishika Samant/The Battalion).
'I was terrified'
April 25, 2024
Scenes from 74
Scenes from '74
April 25, 2024
Farewell from the graduating Battalion staff of 2024
Farewell from the graduating Battalion staff of 2024
The Battalion May 4, 2024

World’s largest mice collection drives research

By Wesley Homes
Research Mice

There’s a massive mouse population at the Texas Institute of Genomic Medicine facility but no exterminator will be called — these mice are used for research at Texas A&M and across the world.
TIGM at Texas A&M boasts the world’s largest collection of mice. The thousands of rodents are used for all sorts of genetic research where the TIGM prepares hundreds of different mouse strains with different genetic traits for researchers in a variety of academic and industry backgrounds.
Andrei Golovko, the production manager at TIGM, handles all of the shipments and business in regards to the mice. He said the process of providing mice for research is rewarding.
“We have mice that have played a role in different kinds of diseases and some people use them for cancer models and research for metabolic diseases,” Golovko said. In the center of the TIGM facility stands a collection of embryonic stem cells and preserved sperm from C57 black mice — this place is known as the library. C57 mice are a type of common lab mice.
“The library contains over 430,000 clones that represent more than 10,000 genes — about 45 percent of the mice genome,” said Ben Morpurgo, TIGM program executive director.  
Morpurgo said Aggies can get involved in the research TIGM conducts.
“We are an available resource for Texas A&M University,” Morpurgo said. “It was only this year where we had over 50 projects for the Texas A&M community, and a lot of those are making a mouse and pronuclear injection. That gives a quick and affordable way for Texas A&M investigators to research.”
In fact, the members of the TIGM team actually have a course for third-year veterinary school students where they can work with mice. TIGM hosts a summer program for high school students where they can learn about embryonic stem cells and genetic engineering. Most of the research for Texas A&M students is complimentary and is readily accessible to the researchers.
TIGM also represents the Texas A&M community internationally by preparing mice for groundbreaking research in international research institutions. So far, TIGM has shipped products to 24 countries worldwide.
What researchers do is extract the embryonic stem cells from the black C57 mice they use as a construct. They proceed to take an embryo donor that is an albino C57 mouse and ovulate them to inject the stem cells.
“The female would later give birth to black and white mice called Chimera, because they are a mix of the black and albino mice. A way we distinguish chimeras from albino are that albino mice have red eyes and chimeras have black ones. These chimera are bred with C57 mice and reproduced in large quantities,” Morpurgo said.
Creating mutations can be a hard task with a one in a million chance of success.
Jonathan Ballard is the scientist in charge of injecting the gene into the mice embryonic stem cells. He said that utilizing these stem cells are critical.
“Creating a success [with mutations] is a one in a million chance. With embryonic stem cells, we can work with millions of cells at a time, thereby increasing the chance of success,” Ballard said. 

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